Discovery of a novel exceptionally potent and orally active Nur77

nuri77Nur77-GFP reporter mice as a useful tool study Nur77 promoter activity during renal IRI. (A) Induction of GFP transcript level mirrored that of Nur77 in the kidney tissues 24 hours after IRI,The role of Nur77 in celastrol-induced mitophagy was illustrated by reduction of autophagic mitochondria (from 12.20 to 0.02%) and diminished COXII degradation in HeLa